Significance analysis of functional categories in gene expression studies: a structured permutation approach

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Significance analysis of functional categories in gene expression studies: a structured permutation approach

MOTIVATION In high-throughput genomic and proteomic experiments, investigators monitor expression across a set of experimental conditions. To gain an understanding of broader biological phenomena, researchers have until recently been limited to post hoc analyses of significant gene lists. METHOD We describe a general framework, significance analysis of function and expression (SAFE), for cond...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2005

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/bti260